Prison Break

Having never seen Prison Break, I have gotten more and more confused about the premise. All of my knowledge comes from FOX's endless promotions of the show. Here's what I've pieced together:

Guy gets accused of a crime he didn't commit.
Brother gets into prison in order to help Guy break out.
Shenanigans ensue.
They break out and meet their father? or something

Now in the new season the Brother guy is back in prison? But, in like China or something?

I guess my main question is, how many times does he have to break out of prison?

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